This year’s topic will focus on the work of Gerald Hart – the 2017 Herbert Tabor Award winner. Dr. Hart established a whole new field of research when he reported in the 1980’s that many cytosolic and nuclear proteins contained Ser and Thr amino acids that were modified by N-acetylglucosamine. Over the years, Dr. Hart and his colleagues have shown that this modification rivals phosphorylation as a fundamental mechanism whereby protein structure and function is regulated in our cells. This O-GlcNAcylation (yes… this is a word – pronounced “OH-Gluck-Nack–illation”) has been shown to regulate all kinds of cellular processes including transcription, protein turnover, neurodegenerative diseases, cellular stress responses and cancer.
Once you get your team registered, you will have access to all the modeling resources that will allow you to explore this topic. . .